An Amplification-Free Surface-Enhanced Raman Scattering Method for Detecting Femtomolar Level of miRNA
Fatema Zerin Farhana, Md Akeruzzaman Shaon, Farjana Haque, Sharmin Aktar, Milkiyas T. Tantu, and Muhammad J. A. Shiddiky. Proceeding of the 29th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2025, F060.W. .
This talk presents a label-free plasmonic nanosensor platform capable of detecting circulating tumor DNA at femtomolar concentrations directly from clinical samples, bypassing conventional amplification steps. The approach leverages localized surface plasmon resonance shifts induced by target hybridization on gold nanostructured substrates.
